Streetwise George and his big childlike friend Lennie are drifters searching for work in the fields and valleys of California. They have nothing except the clothes on their back and a hope that one day they'll find a place of their own and live the American dream. But dreams come at a price. Gentle giant Lennie doesn't know his own strength and when they find work at a ranch he gets into trouble with the boss's daughter-in-law. Trouble so bad that even his protector George may not be able to save him.